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I've been relatively stable with a few jags here and there for almost 2 years, and suddenly I'm experiencing some depression that has me in tears at times, as well as anxiety that results in panic attacks so bad that I feel like I can't breathe. I'm very emotionally labile, reactive to any trigger, sending me to seclusion with my depression.
The only thing that has changed is that I swapped Dexedrine to Bontril-PDM for my weight management (and with Bontril-PDM, off-label ADHD management, idiopathic hypersomnia management, and treatment of refractory bipolar depression). I'm thinking this may be the trigger, but I needed to take a break from Dexedrine because my receptors were too desensitized to it and I was starting to gain weight, sleep all day, become very inattentive (like almost having wrecks kind of inattentive), and feel a little depressed. So I may have identified my trigger, but I need to take a good break from Dexedrine so when I resume it, it will work as it did when I first started it.
My question is how does one prevent depression (neurochemical, not cognitive)? Is there something that can be temporarily added to my cocktail? I see my pdoc Friday. I have tried lithium and it causes seizures. Depakote makes me a zombie. Lamictal causes horrendous acne. I'd rather not add a second antipsychotic. Increasing the antidepressants seem to do nothing.
Should I just get back on Dexedrine ASAP? Or continue to give it a break and try other alternatives? I thought about trying Ritalin again, but a much higher dose than I've tried before, like 40-60 mg in Metadate CD form (the only form I felt anything from with methylphenidate). Concerta and regular Ritalin are useless, and I've heard bad things about Ritalin LA.
Any responses or insight would be much appreciated! Thanks in advance!
This may be more useful for people like me who have pretty much tried it all and are therefore stuck waiting for new research or for something new to come on the market. On my 24th medication and still struggling, I am most definitely treatment resistant. My pdoc specializes in TRD and keeps current on the research. He works/networks with researchers in various places do he almost always has some cutting edge new treatment to suggest and he didn’t disappoint this time. He told me about a new study that looked at metabolites not just in the blood but also the brain via spinal tap. The study (which only looked at subjects with TRD) found that 70% had a shared metabolic deficiency; they all had cerebral folate deficiency. It should be noted that their serum levels were normal, so a regular blood test would NOT pick up on CFD. Treatment involved folinic (NOT folic) acid; unfortunately, it can take 3-4 months to build up enough folate in the brain... but the trade off is that basically ALL subjects who had the deficiency and underwent treatment for better. It’s a small study of course, but my pdoc thought it was very promising, so he recommended I get the spinal tap to test for the deficiency. The test is sometimes covered by insurance, he thought out of pocket it would be about $1,000. And it does require a spinal tap/lumbar puncture, if that matters. For my part, if I could fix myself for $1000 and a needle in the back, sign me up!
Anyway, I’ve always appreciated how my pdoc does so much research into novel treatments, I like to pass on his ideas, particularly for those with doctors willing to try different things.
Hello all, I'm looking for some med experience/anecdotes!
I am bipolar and also have anxiety, ADHD, and PTSD. Currently I'm taking Lamictal (400mg/day), Geodon (80mg/day), and Adderall (25mg/day). I'm looking to change it up because I am seriously struggling with the side effects. Since starting Geodon I am tired all the time (it doesn't help that I'm in the midst of a depressive episode) and I've gained 20+ pounds in two months. I think it's helping with the manic side (or maybe that's just because of the depressive episode I'm in?) but I can't deal with these side effects. The Adderall works great for my ADHD but I think it's making me too edgy/irritable for my liking. On top of it I have been having terrible anxiety lately.
I'm meeting with a new PMHNP next week and I like to research my med options ahead of time so that I feel more informed and can advocate for myself. I'm interested in Wellbutrin because it doesn't have weight gain associated with it, it helps with binge eating and supposedly helps you quit smoking (both current concerns of mine), and can work for both depression and ADHD. I'm also interested in Buspar as a possible anxiety med? I like that it also isn't associated with weight gain and that it isn't supposed to be sedating.
I've also taken Abilify in the past (before I took Geodon) and didn't experience any terrible side effects other than it making me sleepy but maybe combined with the right thing that wouldn't be as much of an issue?
Anyone have experience with this combo or a similar one? Any and all feedback appreciated! The med game is so overwhelming.
Hoping someone can offer some insight to what is happening with me?
I've been taking Ritalin consistently over a year again. Pulled me out of a bad anhedonia - I'm focused, motivated and goal driven. Mood was great the last 5 months. Now, I'm having intense meltdowns in the afternoon/eve. Stress-related. Internal pressure to succeed. I've lost many years to depression, being unproductive (was even bed-ridden from episodes).I've worked REALLY hard to pull out, and had one of the best 5-month "good periods" in a long time. I'm afraid of going back to that...
I wonder if the Ritalin is in fact causing mood swings now. I get crying spells: stress, perfectionism, anxiety, irritability. I know everyone here will probably suggest adding an antidepressant again, but to be honest the A/Ds increase my apathy and anhedonia (I have Double depression - chronic low mood/no pleasure, with intermittent severe episodes). I don't know what to do, this seems to be stress-related as I've been so focused on Ritalin and wearing myself down.
My main coping mechanism lately is studying, reading, working, writing as much as possible to distract myself from my unrelenting unhappiness with my life and myself. Basically, nothing is fun or enjoyable for me, I can't enjoy going for walks, hobbies or even watching tv series. I think the Ritalin has motivated me (good) but I've become a workaholic robot who only gets satisfaction from output, accomplishing goals and achieving perfection. I feel like a complete FAILURE if I'm not learning or working the entire day until bedtime!!! Is this similar to a Hypo or "Mixed" episode?? I don't want doc to label me as Bipolar and then quit prescribing Ritalin.
So I've been depressed and have had severe anxiety for 3 years. Antidepressants make me hypomanic (kinda) and triggers unstable mood. I don't fit in the usual description of bipolar, but there is definitely something not right about the way i react to antidepressants - feeling high, warm, racing thoughts x 100, gets overly chatty etc.
I've tried the following moodstabilizers
Abilify (made me hypomanic)
Seroquel (made me hypomanic)
Depakote/valproate (still taking)
This depression is killing me, but my p.doc. won't prescribe me lithium. Tried two different doctors. What are your thoughts?