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Zoloft or Viibryd versus Effexor? tried about everything


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Anyone find Zoloft more motivating than Effexor? Any weight gain? (it made me insomniac with psychosis 20 years ago). But meds often act differently over time. I've already done trials (some multiple times) of:

Prozac (lethargic), Celexa (fatigue/apathy), Lexapro (similar to prozac), Cymbalta (vigilance/restlessness legs, but dissociative mind/feeling), Wellbutrin (no effect), Trintillex (no effect), Remeron (sedating/+appetite), Notryptaline (don't recall), Abilify (++appetite, RLS), ..Doc won't RX MAOIs and says that TCAs typically more sedating effects.

Basically, I don't want to take more than 3 meds (keeping with Lamictal & Ritalin). I want to avoid A/Ps...I like the calming feeling of Prozac & Effexor, but it's as if I am in this fuzzy cloud and I can't move or do anything, comfortably numb. Totally apathetic, in addition to sexual dysfunction, maybe my dosage is wrong. I'm also considering Viibryd, but don't know if it works on Serotonin...?

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3 minutes ago, Blahblah said:

Anyone find Zoloft more motivating than Effexor? Any weight gain? (it made me insomniac with psychosis 20 years ago). But meds often act differently over time. I've already done trials (some multiple times) of:

Prozac (lethargic), Celexa (fatigue/apathy), Lexapro (similar to prozac), Cymbalta (vigilance/restlessness legs, but dissociative mind/feeling), Wellbutrin (no effect), Trintillex (no effect), Remeron (sedating/+appetite), Notryptaline (don't recall), Abilify (++appetite, RLS), ..Doc won't RX MAOIs and says that TCAs typically more sedating effects.

Basically, I don't want to take more than 3 meds (keeping with Lamictal & Ritalin). I want to avoid A/Ps...I like the calming feeling of Prozac & Effexor, but it's as if I am in this fuzzy cloud and I can't move or do anything, comfortably numb. Totally apathetic, in addition to sexual dysfunction, maybe my dosage is wrong. I'm also considering Viibryd, but don't know if it works on Serotonin...?

Is this for mainly depression or anxiety? If depression- there is also Pristiq (related to Effexor) and fetzima, which is more off the beaten path so some docs won’t Rx, which acts very strongly on norepinephrine 

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1 minute ago, Iceberg said:

Is this for mainly depression or anxiety? If depression- there is also Pristiq (related to Effexor) and fetzima, which is more off the beaten path so some docs won’t Rx, which acts very strongly on norepinephrine 

I'm pretty stable at moment, but have mainly chronic/moderate depression, ruminations...and I have monthly "blips" of more severe depression. So something to lift the depression without making me agitated, or give me bad insomnia.

I'll ask about Pristiq and Fetzima...though I remember being on Cymbalta (greater NE effect) and I felt really physically restless, like sort of wired but my mind felt slow and dissociated, like disconnected.

Ugh just realized that Viibryd is only in the US, well scratch that. I'm also considering maybe descreasing the Effexor (so more an SSRI) and trying to get doc to up my Ritalin to balance the Serotonin/Dopamine..

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Zoloft has a Dopaminergic effect. My pdoc said that is almost nonexistent, but subjectively, being on it twice, it was motivating and mind-clearing, like a low dose Ritalin, even on 50mg (low).

I switched from Zoloft to Prozac because I remember it being better long time ago... now I am not so sure about it.

Anyhow, more energizing than Effexor.

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Thanks @HydroCat I think my brain has changed enough in the last 20 years it would no way have the same effect as it did as a teenager. Was the first med I ever tried, and my brain has been through a couple dozen med changes now! I think Zoloft has a longer half-life also, maybe easier to come off of than Effexor.

Do you think you will switch back? Was there a particular side effect in Zoloft that made you want to switch? Seems there aren't many people here taking Zoloft these days for some reason.

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3 minutes ago, Blahblah said:

Thanks @HydroCat I think my brain has changed enough in the last 20 years it would no way have the same effect as it did as a teenager. Was the first med I ever tried, and my brain has been through a couple dozen med changes now! I think Zoloft has a longer half-life also, maybe easier to come off of than Effexor.

Do you think you will switch back? Was there a particular side effect in Zoloft that made you want to switch? Seems there aren't many people here taking Zoloft these days for some reason.

Sertraline (generic Zoloft) was the first med I have ever been on.

Prozac, second one, was more stable... so I've remembered.

I have been switching many meds for a few years, then back to one of these, +Wellbutrin.

I will give Prozac a fair try (not really a choice with such a long half-life) but I may eventually stick to Zoloft.

Switching fast back and forth had no withdrawal effects whatsoever. Effexor is a different animal.

 

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  • 3 weeks later...

@Blahblah I would say Viibryd is definitely worth a shot if your insurance will cover it without a fuss. It was very activating for me. Granted I wasn't being treated with a mood stabilizer, but even my pdoc has said to me that his perception of it is that it's activating for most people. Known for having VERY little sexual dysfunction and somewhat less anhedonia.

However, some people don't tolerate Viibryd. You should give it 4-6 weeks before you throw in the towel, but some people don't mix well with the GI side effects, and it can cause insomnia because of how activating it is. Just things to keep in mind going into it.

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