Rabbit37 Posted July 17, 2019 Share Posted July 17, 2019 Started taking trazodone again. Weirdly, it’s working this time for sleep, and only 50mg. No hangover per se, feel okay when I get up, but I’m having weird bouts of really bad irritation and/or frustration. It comes on suddenly, too, I’ll be feeling okay, then the next minute want to hurl things at the wall. Usually starts late morning, maybe 13-14 hours after taking it. And not every day, but at least half the time. I didn’t have this prior to starting it, so thinking it’s gotta be the cause. Has anyone experienced this? It’s not bad enough to warrant calling pdoc, it was hard enough deciding to go back on a sleep med as it is. But it’s bad enough to sometimes resort to Ativan to calm down. Link to comment Share on other sites More sharing options...
Iceberg Posted July 18, 2019 Share Posted July 18, 2019 8 hours ago, Rabbit37 said: Started taking trazodone again. Weirdly, it’s working this time for sleep, and only 50mg. No hangover per se, feel okay when I get up, but I’m having weird bouts of really bad irritation and/or frustration. It comes on suddenly, too, I’ll be feeling okay, then the next minute want to hurl things at the wall. Usually starts late morning, maybe 13-14 hours after taking it. And not every day, but at least half the time. I didn’t have this prior to starting it, so thinking it’s gotta be the cause. Has anyone experienced this? It’s not bad enough to warrant calling pdoc, it was hard enough deciding to go back on a sleep med as it is. But it’s bad enough to sometimes resort to Ativan to calm down. I have - problem is i won’t be very helpful because it was in the summer while I was having other issues... and the number one common summer issue for me is irritability Link to comment Share on other sites More sharing options...
argh Posted July 18, 2019 Share Posted July 18, 2019 even at super low doses, it has the chance of causing activation, good or bad. i used to take 50mg every night. I'm now to only take 25mg, as my mood is in an upswing. Link to comment Share on other sites More sharing options...
CrazyRedhead Posted July 18, 2019 Share Posted July 18, 2019 (edited) I've been taking Traz for over 3 years now, I'm up to 200mg. I don't remember experiencing any irritation or frustration with it when I started......Maybe it's wearing off when you get irritated or frustrated?..........It has a half-life of about 10-12 hours. Edited July 18, 2019 by CrazyRedhead Link to comment Share on other sites More sharing options...
argh Posted July 18, 2019 Share Posted July 18, 2019 It might be a bipolar thing as trazodone is an AD. By all accounts a crap AD, but it can cause issues. 1 Link to comment Share on other sites More sharing options...
mikl_pls Posted July 20, 2019 Share Posted July 20, 2019 It also has a metabolite, mCPP, which is rather stimulating. At just 50 mg, the blood levels of mCPP might not be significant enough to cause irritability, but if you're sensitive to it, it can probably do this. It might be the 5-HT2C agonism causing this (trazodone in higher doses is a 5-HT2C antagonist, yet when you increase the dose, you increase blood levels of mCPP too). 1 Link to comment Share on other sites More sharing options...
Rabbit37 Posted July 20, 2019 Author Share Posted July 20, 2019 On 7/18/2019 at 12:15 AM, Iceberg said: I have - problem is i won’t be very helpful because it was in the summer while I was having other issues... and the number one common summer issue for me is irritability I do get irritable in the heat, although I’m not sure that’s a factor, but thanks. On 7/18/2019 at 3:39 PM, argh said: even at super low doses, it has the chance of causing activation, good or bad. i used to take 50mg every night. I'm now to only take 25mg, as my mood is in an upswing. On 7/18/2019 at 4:01 PM, argh said: It might be a bipolar thing as trazodone is an AD. By all accounts a crap AD, but it can cause issues. It’s funny, I knew it was an AD, but that didn’t click. I’ve taken AD’s before, but I’ve always had a strong AAP on board as well, right now I’m just taking lithium, having had to drop seroquel. Maybe it’s too much for me. 43 minutes ago, mikl_pls said: It also has a metabolite, mCPP, which is rather stimulating. At just 50 mg, the blood levels of mCPP might not be significant enough to cause irritability, but if you're sensitive to it, it can probably do this. It might be the 5-HT2C agonism causing this (trazodone in higher doses is a 5-HT2C antagonist, yet when you increase the dose, you increase blood levels of mCPP too). Thank you, mikl, although if you said the above in Klingon I might’ve had a better understanding 😂 I did understand “which is rather stimulating”, and that might be the problem. Thanks all. I wound up taking a double dose of unisom last night (the doxylamine version), and slept five hours, which is incredible. Why does sleep have to be so difficult? 1 Link to comment Share on other sites More sharing options...
argh Posted July 21, 2019 Share Posted July 21, 2019 There’s something about light and heat that makes me feel like my meds are overstimulating. I think i would have been perfectly stable recently if it didnt get significantly brighter and like 20 degrees hotter. as far as sleep goes, well fuck us thats why. 1 Link to comment Share on other sites More sharing options...
Recommended Posts