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Vortioxetine(Brintellix) anyone?

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I've been taking Trintellix (the name used for this drug in the US) for about the last 3 months.

Positive: Well, it's certainly helping with my depression, so far.

Negative: I experience nausea after taking it, which lasts for about two hours or so. This is extremely annoying, as you can imagine. But I'd rather suffer through a little nausea than go back to feeling like absolute shit.

As for cognition - I would say my head and brain are definitely clearer, especially after the nausea subsides.

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On 7/28/2019 at 12:38 AM, the maze runner said:

Anyone has experience of this antidepressant. Can someone outline the positives and negatives. What were the effects on cognition?

Mostly just positives really. In the beginning (like the first two weeks) you may notice nausea or itchy skin. Both can be resolved with anti-histamines like Pepcid (famotidine) or Zantac (ranitidine) for stomach issues and Zyrtec (cetirizine) or Xyzal (levocetirizine) for itchy skin (pruritis).

It is stimulating, particularly in the beginning. It's strange in that it's stimulating at the bottom end and top end of the dose range but around 10-15mg it's more calming I think, but without sacrificing the positive stimulation.

I couldn't tell at first the positive effects it was having on my cognition until I tried to come off of it and I realized I was having returning cognitive issues that I never knew I had before Trintellix.

Another positive is that it should have a lower rate of sexual dysfunction at least on moderate doses. Based on clinical data there were still instances of sexual dysfunction for men at the highest dose of 20mg, but post-marketing data shows it can happen for women as well.

Honestly, if someone gave me an option of the older ones next to Trintellix, based on my experience, I would pick the Trintellix every time unless I couldn't afford it for some reason. Then I would probably fall back to Pristiq (desvenlafaxine) because it's generic now.

Recommendation to start low and go slow. The dosage information says start at 10mg and decrease to 5mg if there are tolerability issues, but my experience says start at 5mg for at least the first week or two.

@the maze runner what is your diagnosis? Trintellix is only approved for major depressive disorder but a study in Italy showed that Trintellix does have mood stabilizing effects when used in conjunction with a mood stabilizer.

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