Jump to content
CrazyBoards.org

ln009

Stimulants help with depression?

Recommended Posts

Does anyone find that stimulants are helpful in treating depression? Is is only in the short-term or can you take them long-term?

Does anyone do stimulant monotherapy or do you take the stimulant in addition to other meds?

Thank you!!

Share this post


Link to post
Share on other sites

I'm not going to talk about the current data on this. I'm going to talk about my own extensive experience with using methylphenidate-based and amphetaminergic meds to treat my decades-long severely Treatment Resistant Depression.

In a nutshell, the four Adderall doses I take every day afford me brief glimpses of feeling "normal". I briefly want to do things, care about things and feel mostly human basically. Other than those periods, I desperately want to be dead.

And before everyone jumps on the "stimulants are short term, this won't last" wagon, I've been taking this amount of Adderall for over a year. Yes, it is hugely less effective (for my depression) than when first prescribed, but it's still literally invaluable to me for the aforementioned reasons.

I cannot convey how important stimulants are to me in my fight against TRD.

FTR my regimen is Lexapro, Rexulti, Abilify, Trazodone, Buspar, Adderall.

Pete

( X-post from http://dr-bob.org/babble/20190728/msgs/1105693.html )

  • Like 2

Share this post


Link to post
Share on other sites

I haven't used them personally. I included them in a list of possibilities in conversation with my pdoc and he said he never prescribes them as an adjunct for MDD. From my reading, not all pdocs share that stance. Stimulants do get included in some treatment guidelines as a (roughly) third-line adjunct treatment. The research I looked at had fairly mixed results, but I was running low on better options, so I wanted to consider it

  • Like 1

Share this post


Link to post
Share on other sites

Stimulants are sometimes used in cocktails that are overly sedating. I feel amphetamine in my cocktail helps my MDD. Back when MAOI's were used commonly, amphetamine was often added to it as an augmenter.

Share this post


Link to post
Share on other sites

I don't think I could survive without my stimulant to be honest. The past year and a half I've been on Dexedrine 60 mg has been one of the best years I've had in a long, long time. It is probably one of the main meds that really helps both my ADHD, mood, and motivation. I did kinda crash in February and my pdoc and I are still trying to get my cocktail right (may just found the right combination for now).

  • Like 2

Share this post


Link to post
Share on other sites
On 8/11/2019 at 3:49 PM, ln009 said:

Does anyone find that stimulants are helpful in treating depression? Is is only in the short-term or can you take them long-term?

Does anyone do stimulant monotherapy or do you take the stimulant in addition to other meds?

Thank you!!

They help me with motivation and focusing despite my depressive symptoms as well as countering sedation from from other meds. I’ve never heard of stim monotherpy for depression though 

  • Like 1

Share this post


Link to post
Share on other sites
On 8/12/2019 at 3:11 PM, notloki said:

Stimulants are sometimes used in cocktails that are overly sedating. I feel amphetamine in my cocktail helps my MDD. Back when MAOI's were used commonly, amphetamine was often added to it as an augmenter.

Nardil + Ritalin and Nardil + Adderall were the best combos I've ever been on, and that's saying something. I felt Normal, energetic, ready to tackle the day, could think laterally, was resilient to failure, robust, interpersonal, witty. It was an amazing period. Then my PDoc got cold feet and stopped prescribing the stimulant and I descended back into hell.

  • Sad 1

Share this post


Link to post
Share on other sites
11 hours ago, sming said:

Nardil + Ritalin and Nardil + Adderall were the best combos I've ever been on, and that's saying something. I felt Normal, energetic, ready to tackle the day, could think laterally, was resilient to failure, robust, interpersonal, witty. It was an amazing period. Then my PDoc got cold feet and stopped prescribing the stimulant and I descended back into hell.

Same with me for Parnate + Adderall, but it didn't last long. I was initially on Parnate 20 mg, and after a few months it kinda lost its potency, so my pdoc took me off of Adderall and grudgingly moved me up to Parnate 40 mg (without stimulant), and I crashed through the floor.

  • Sad 1

Share this post


Link to post
Share on other sites
18 hours ago, sming said:

Nardil + Ritalin and Nardil + Adderall were the best combos I've ever been on, and that's saying something. I felt Normal, energetic, ready to tackle the day, could think laterally, was resilient to failure, robust, interpersonal, witty. It was an amazing period. Then my PDoc got cold feet and stopped prescribing the stimulant and I descended back into hell.

I'm really sorry to hear that. I hope you have some choices to potentially help.

7 hours ago, mikl_pls said:

Same with me for Parnate + Adderall, but it didn't last long. I was initially on Parnate 20 mg, and after a few months it kinda lost its potency, so my pdoc took me off of Adderall and grudgingly moved me up to Parnate 40 mg (without stimulant), and I crashed through the floor.

I'm sorry. I hope for all of us we can find some answers.

Share this post


Link to post
Share on other sites
19 hours ago, ln009 said:

I'm really sorry to hear that. I hope you have some choices to potentially help.

Thank you, that's kind of you to say. I hear tomorrow whether I'm suitable for VNS, which is about the only thing I've got left to try. 

Edited by sming

Share this post


Link to post
Share on other sites

 

On 8/15/2019 at 2:53 PM, ln009 said:

I wish you the best...please keep us posted.

A bit tardy, but here's my update. The TRD squad at Mount Sinai, NYC said I had to try Ketamine first. Cue huge insurance faff w.r.t. esketamine that lasted weeks, end result being I had to switch to infusions. I've done the 4 "foundational" infusions and despite the profound, amazing experiences, am no better. Hence the TRD squad are to cogitate this Thursday w.r.t. VNS/DBS. Please cross your proverbials for me.

Pete

Share this post


Link to post
Share on other sites

Update #2: I tried Ketamine and whilst it was an amazing experience, it did absolutely nothing. Now the TRD squad are insisting I try an SCS device (for my chronic pain) before I try DBS ¯\_(- -)_/¯  I am gutted about this because my depression is much more incapacitating and devastating than my chronic pain is, and if the SCS device works, I won't be able to get DBS :( 

Edited by sming

Share this post


Link to post
Share on other sites
29 minutes ago, sming said:

Update #2: I tried Ketamine and whilst it was an amazing experience, it did absolutely nothing. Now the TRD squad are insisting I try an SCS device (for my chronic pain) before I try DBS ¯\_(- -)_/¯  I am gutted about this because my depression is much more incapacitating and devastating than my chronic pain is, and if the SCS device works, I won't be able to get DBS :( 

hey @sming do you know what the official criteria is for TRD? Does this mean that you have had zero benefit from most meds, and it's severe depression that does not let up (even a few days?) Doctors I've met seem to think a person must be completely incapacitated (i.e. not able to work/function) and have no response to any treatments, in order to be treatment-resistant

Edited by Blahblah

Share this post


Link to post
Share on other sites

@Blahblah Off the top of my head, I do not. My doctors have no problem describing me as TRD when I show them the list of some 70+ medications and treatments that have failed me!

OTOH they are generally puzzled that I'm able to hold down a job. As am I, TBH. I'm astonished I haven't been fired more often (3 times so far). I also have kids which confounds doctors somewhat. Having kids, whilst I dearly love them (when able to), in the cold hard light of day, was probably a big mistake.

Pete

Edited by sming

Share this post


Link to post
Share on other sites
3 minutes ago, sming said:

@Blahblah Off the top of my head, I do not. My doctors have no problem describing me as TRD when I show them the list of some 70+ medications and treatments that have failed me!

OTOH they are generally puzzled that I'm able to hold down a job. As am I, TBH. I'm astonished I haven't been fired more often (3 times so far). I also have kids which confounds doctors somewhat. Having kids, whilst I dearly love them (when able to), in the cold hard light of day, was probably a big mistake.

Pete

Just curious, what are the residual symptoms you deal with? Is it more apathy / anhedonia or more severe, labile, compulsive, suicidal ideation episodes?

Share this post


Link to post
Share on other sites
6 minutes ago, Blahblah said:

Just curious, what are the residual symptoms you deal with? Is it more apathy / anhedonia or more severe, labile, compulsive, suicidal ideation episodes?

Sure. It's both. Every day, precisely as my Adderall wears off, deep & powerful feelings of worthlessness and emptiness fill me - until my next dose. I also experience dysthymia, all-encompassing negative, distorted cognitions and beliefs, extreme anhedonia and "lack of energy" e.g. reaching for my glass of water feels like running a marathon.

When my meds are in transition for example, also add on top derealization, horrific feelings of terror, visions of terror, feelings of impending doom, visual darkness - the works.

From the little I know about you, you're somewhat on the same tracks (unfortunately) ?

PS - completely forgot to mention my TR pure OCD. The topic of my OCD is <drum roll>... the fear that I'll spontaneously kill myself if I allow myself to feel even slightly hurt or depressed. FFS.

Edited by sming

Share this post


Link to post
Share on other sites
13 minutes ago, sming said:

Sure. It's both. Every day, precisely as my Adderall wears off, deep & powerful feelings of worthlessness and emptiness fill me - until my next dose. I also experience dysthymia, all-encompassing negative, distorted cognitions and beliefs, extreme anhedonia and "lack of energy" e.g. reaching for my glass of water feels like running a marathon.

When my meds are in transition for example, also add on top derealization, horrific feelings of terror, visions of terror, feelings of impending doom, visual darkness - the works.

From the little I know about you, you're somewhat on the same tracks (unfortunately) ?

PS - completely forgot to mention my TR pure OCD. The topic of my OCD is <drum roll>... the fear that I'll spontaneously kill myself if I allow myself to feel even slightly hurt or depressed. FFS.

Yikes. Yeah, I can relate to much of this. Do stimulant holidays help at all? I'm trying to power through a 2-month one....2.5 more weeks to go....

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


×
×
  • Create New...