argh Posted August 20, 2019 (edited) . Edited September 16, 2020 by argh Quote Share this post Link to post Share on other sites
basuraeuropea Posted August 20, 2019 https://www.ncbi.nlm.nih.gov/pubmed/16400245 related link for glutamate and anxiety disorders. Quote Share this post Link to post Share on other sites
Melancholya Posted August 20, 2019 Does lamotrigine basically increase glutamate @argh? Or level it out or something? (I realise it's probably not that simple...) Quote Share this post Link to post Share on other sites
basuraeuropea Posted August 20, 2019 23 minutes ago, Melancholya said: Does lamotrigine basically increase glutamate @argh? Or level it out or something? (I realise it's probably not that simple...) lamotrigine inhibits the release of glutamate. https://hopes.stanford.edu/lamotrigine/#how-can-lamotrigine-reduce-glutamate-release Quote Share this post Link to post Share on other sites
argh Posted August 20, 2019 (edited) On 8/20/2019 at 3:30 AM, Melancholya said: Does lamotrigine basically increase glutamate @argh? Or level it out or something? (I realise it's probably not that simple...) It's been said to be a modulator, though i don't see how it would know if it needs to bump it up or not. @basuraeuropea link hits the nail on the head i believe. Excellent link. Glutamate is indicated in memory and congnition, so it also makes sense that a too high level of lamotrigine will cause cognition and memory issues. I suspect that is why taking NAC while on lamotrigine gives me the case of the stupids, where alone they don't..aphasia aside. I suppose in real world RCTs it makes sense that it clearly works on BP depression as there's still an excess of glutamate in that case, per the original article. With respect to unipolar depression, it does make sense how RCTs have been largely negative due to the glutamate deficit. For the positive ones in MDD it could be the situation that's described in my favorite site, psycheducation.org, where this is no actual/explicit hypomania but there's some occult BP stuff going on. Edited September 22, 2019 by argh low does not make sense 1 Quote Share this post Link to post Share on other sites
basuraeuropea Posted August 20, 2019 on memantine, a glutamatergic antagonist, as a treatment approach for anxiety-spectrum disorders -- https://www.hindawi.com/journals/crips/2012/749796/ as well as major depressive disorder -- https://www.sciencedirect.com/science/article/pii/S0014299918301778 Quote Share this post Link to post Share on other sites
