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I've been experiencing depersonalization frequently recently but I don't understand why. I probably don't fit the criteria of depersonalization disorder so the only other reason I could experience is if I used a psychedelic substance, which I do not. I've been wondering if depression is the cause of the depersonalization as it often, but not always, happens during MDD episodes. Could this be correct?

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Sort of. DP/DR is more associated with extreme, prolonged anxiety. Since depression is highly comorbid work anxiety, they often occur together. HTH. 

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I don't remember being anxious at the time I experienced derealization during my first major depressive episode. Trauma was a factor, though.

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