Kaona Posted September 12, 2019 Share Posted September 12, 2019 Hi all. I was started on Clomipramine in mid July. I was increased to 300 mg a couple of weeks ago. I used to take it all at bedtime, but ever since my dosage was upped, I take it 4 times a day, including bedtime. Is it typical for the doses to be spaced out throughout the day like this? It just seems strange to me, and taking it this many times daily is slightly annoying. Especially because it makes me unbelievably tired and hard to function. Those effects are great at night and help me sleep, but not so great to have throughout the day. I will be talking to my doctor about this, just am not sure when I can get an appointment next. Link to comment Share on other sites More sharing options...
basuraeuropea Posted September 13, 2019 Share Posted September 13, 2019 the half-life of clomipramine its active metabolite desmethylclomipramine are super long, so i don't see why you can't take the dose all at once before bed. Link to comment Share on other sites More sharing options...
mikl_pls Posted September 17, 2019 Share Posted September 17, 2019 When I took clomipramine, I took 225 mg all at bedtime. I couldn't stand that medicine. 300 mg is a mighty high dose though, beyond 250 mg increases risk of seizures I believe. Just please be careful with that dose. Clomipramine is a heavy hitter of a medicine, both therapeutic effects-wise and side effects-wise. Link to comment Share on other sites More sharing options...
CrazyRedhead Posted September 17, 2019 Share Posted September 17, 2019 (edited) When I tried clomipramine, I was on 250mg, and I took it all at bedtime.....I don't think there's a need to dose it more than once a day....I no longer take it. 300mg is a very high dose, like @mikl_pls said.....Just be careful and let your doc know if you have any unusual symptoms. Edited September 17, 2019 by CrazyRedhead Link to comment Share on other sites More sharing options...
Kaona Posted September 19, 2019 Author Share Posted September 19, 2019 Thank you all so much for your responses. Next time I am able to see my doctor, I will ask about the possibility of taking all of it at bedtime. Also, thanks for your concern about the high dosage I am on. I weigh considerably more than the average person, so I believe that's why my dose is a bit higher. I'm not having any ill side effects other than the extreme tiredness during the day, but hopefully my doc will switch it to allow me to take it all together at night. Then that should solve that. I don't feel amazing or anything, but I've been on countless other antidepressants and this one by far has been the most effective and helpful. 1 Link to comment Share on other sites More sharing options...
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