clinic Posted October 20, 2019 Share Posted October 20, 2019 (edited) It looks like i only tolerate sedating antidepressants. I've been on paroxetine since 2.5 years. I cant tolerate activating antidepressants. Any suggestions ? I would like to add another antidepressant for mood and panic disorder. Following ADs did not work for me Fluoxetine,Escitalopram, Fluvoxamine, Desvenlafaxine, Vilazodone, Sertraline,Clomipramine,Trazodone, Venlafaxine,Buspirone,Tianeptine Edited October 20, 2019 by clinic Quote Link to comment Share on other sites More sharing options...
Depressive1 Posted October 20, 2019 Share Posted October 20, 2019 Remeron and Elavil are both sedating AD’s. 1 Quote Link to comment Share on other sites More sharing options...
CrazyRedhead Posted October 20, 2019 Share Posted October 20, 2019 (edited) 1 hour ago, Depressive1 said: Remeron and Elavil are both sedating AD’s. I agree.....Another suggestion I might add is low-dose doxepin. Edited October 20, 2019 by CrazyRedhead Quote Link to comment Share on other sites More sharing options...
mikl_pls Posted October 20, 2019 Share Posted October 20, 2019 (edited) Trimipramine is another one that is pretty sedating. It also increases REM sleep rather than suppressing it like most antidepressants. It also has antipsychotic properties (D2 and 5-HT2A antagonism) as well. Edited October 21, 2019 by mikl_pls Quote Link to comment Share on other sites More sharing options...
Iceberg Posted October 21, 2019 Share Posted October 21, 2019 Tofranil? Quote Link to comment Share on other sites More sharing options...
argh Posted October 21, 2019 Share Posted October 21, 2019 Another vote for mirtazapine. Holy shit was that sedating..I think I was too sedated to feel panic or anxiety. Quote Link to comment Share on other sites More sharing options...
mikl_pls Posted October 21, 2019 Share Posted October 21, 2019 Related to mirtazapine, is mianserin available where you live? It's related to mirtazapine. Neither mirtazapine nor mianserin are reuptake inhibitors; rather, they antagonize serotonin and noradrenergic receptors in order to enhance release of serotonin and norepinephrine, as well as indirectly enhance 5-HT1A signaling. Amoxapine is somewhat sedating (for me anyway). It's a tetracyclic antidepressant that is a metabolite of the typical antipsychotic loxapine. It is a relatively potent and selective norepinephrine reuptake inhibitor with little serotonin reuptake inhibition. It also has antipsychotic properties (5-HT2A and D2 antagonism), and metabolizes into compounds that have even more potent D2 antagonism. That being said, loxapine, which is similar to clozapine in low doses (except without the risk of agranulocytosis, seizures, etc., and requirement to get frequent blood testing done), could be an idea for an adjunct to clozapine, as it would confer antidepressant properties as well with its metabolite amoxapine. Maprotiline is another tetracyclic antidepressant that is pretty sedating. I've personally never taken it before, but it has pretty strong affinity to the H1 receptor. No antipsychotic properties like trimipramine or amoxapine or anything though. It's probably the most selective norepinephrine reuptake inhibitor, with almost no serotonin reuptake inhibition at therapeutic doses, but it isn't as potent a NRI as desipramine. Quote Link to comment Share on other sites More sharing options...
HydroCat Posted October 22, 2019 Share Posted October 22, 2019 (edited) Mirtazapine (30-45mg) made me fall asleep on my chair at work for about an hour. Every day, untill I switched it. My colleagues were taking pictures of me sleeping. I used to blame it on the Benzo I was taking at the time but it was Mirtazapine after all. Just a note: I cannot recommend Mirtazapine because it gave me depersonalization which was scary as hell. Of coure, YMMV. Edited October 22, 2019 by HydroCat Quote Link to comment Share on other sites More sharing options...
argh Posted October 22, 2019 Share Posted October 22, 2019 agomelatine? Quote Link to comment Share on other sites More sharing options...
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