the maze runner Posted November 16, 2019 Share Posted November 16, 2019 I am now on clozapine for about 4 months and my mood is tremendously boosted. Is there any particular reason for why this should be so. Quote Link to comment Share on other sites More sharing options...
aura Posted November 17, 2019 Share Posted November 17, 2019 Clozapine has been a wonder drug for me, both in terms of mood and psychosis. I've been on it for more than a year now and no hospitalizations. Quote Link to comment Share on other sites More sharing options...
notloki Posted November 17, 2019 Share Posted November 17, 2019 It is the original atypical, it is a strong AP and works when others do not. I seem to remember it has a lower risk of Tardive Dyskinesia. Quote Link to comment Share on other sites More sharing options...
netsavy006 Posted November 21, 2019 Share Posted November 21, 2019 I really like clozapine. I've been on it for a little over 9 years now and it really stabilizes my mood and rids my psychosis. Quote Link to comment Share on other sites More sharing options...
the maze runner Posted November 21, 2019 Author Share Posted November 21, 2019 yeah clozapine is kickass. Quote Link to comment Share on other sites More sharing options...
Will Posted January 8, 2020 Share Posted January 8, 2020 (edited) Here is a fairly recent article about clozapine. I had been considering it for my own use when I ran across this. https://www.vice.com/en_us/article/qvgdj3/the-psychiatric-wonder-drug-that-almost-no-one-is-using Edited January 8, 2020 by Will Quote Link to comment Share on other sites More sharing options...
mikl_pls Posted January 8, 2020 Share Posted January 8, 2020 Its serotonin antagonism is much stronger than dopamine antagonism for one, and its active metabolite is a dopamine partial agonist like Abilify, Rexulti, and Vraylar, but with lower intrinsic activity. That's just my guess. Quote Link to comment Share on other sites More sharing options...
Simba Cub Posted January 8, 2020 Share Posted January 8, 2020 It's like a jackhammer to the head. It will leave you poleaxed and craving sugar, but the upsides are enormous. I'm on 450mg, half way to the max roughly, and it's helped greatly. Be aware of toxicity levels - I was on 550mg but it was poisoning me. Quote Link to comment Share on other sites More sharing options...
psychwardjesus Posted January 17, 2020 Share Posted January 17, 2020 Honestly, researchers don't really know because it doesn't follow the typical formulation of antipsychotic meds, i.e. strong affinity for dopamine antagonism, especially at D2 as it's a particularly weak D2 blocker unlike most other AP's, and thus doesn't fall into the dopamine-psychosis paradigm either. Quote Link to comment Share on other sites More sharing options...
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