Jump to content

Zyprexa's anti-depressant effects w/o SSRI

Recommended Posts


Wondering if there might be some personal or anecdotal evidence out there that Zyprexa (olanzapine) might achieve an anti-depressant response without pairing it with an SSRI like fluoxetine (i.e. Symbyax, "OFC"). My doctor is trying to avoid going back on Seroquel XR and has given me the dosing wiggle room of 2.5-7.5 mg to test drive to see if we might be able to have some success.

FWIW, I can't tolerate SSRI's, and am in somewhat of a mixed depressive state with high anxiety.

Link to comment
Share on other sites

I take Zyprexa personally when I'm in a pinch from time to time to get out of major depressive episodes, but I'm on an SSRI, so I don't think that counts.

Theoretically, it should provide antidepressant benefits on its own due to 5-HT2A/2C antagonism that are stronger than that of the D2 antagonism (so I think low doses would be more antidepressant, then higher doses would begin to recruit the D2 antagonism to a significant degree).

I hope you get the relief that you need.

Link to comment
Share on other sites

  • 1 month later...

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • Create New...