Half life question

[clinic]

If you have been taking 200mg clozapine for years and lets say its half life is 24 hours.

And then one day u accidentenly take 400mg instead of 200mg clozapine. Then you go back to 200mg on next day.

Maybe im miscalculating. if i take 400mg, then the next day it will be half of 400mg which is 200mg, then i will take 200mg clozapine next day at bedtime, then will it again go back to 400mg in my body ?

In other words will my body have permanently 400mg clozapine, even if i go back and take 200mg daily ?

@mikl_pls

Edited January 20, 2020 by clinic

[CrazyRedhead]

5 hours ago, clinic said:

In other words will my body have permanently 400mg clozapine, even if i go back and take 200mg daily ?

No....If you take 400mg one time, then go back to 200mg as your daily dose, the excess clozapine from the 400mg dose will eventually be eliminated.

Clozapine has an elimination half-life of around 14 hours:   https://en.wikipedia.org/wiki/Clozapine#Pharmacokinetics

Edited January 20, 2020 by CrazyRedhead

[mikl_pls]

57 minutes ago, CrazyRedhead said:

No....If you take 400mg one time, then go back to 200mg as your daily dose, the excess clozapine from the 400mg dose will eventually be eliminated.

Clozapine has an elimination half-life of around 14 hours:   https://en.wikipedia.org/wiki/Clozapine#Pharmacokinetics

This.

Also, if you accidentally double your dose, don't get too analytical about it. Just go back to your normal dosing. If you try to overanalyze things like this it will interfere with your treatment and you will not do well. I know this because I do this myself, and have to be called out by my pdoc when I'm doing it because I lack insight about it so much. It almost becomes a psychotic preoccupation for me unless I have an intervention with my pdoc about it.