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Hi Folks,

So i have a Pdoc phone appointment next Thursday..I'm gunna ask for a trial of quetiapine..I think he should be ok with it as quetiapine was suggested at my first appointment but unitll i'd had a ECG he was unwilling to perscribe it ..I've since had the ECG...I tried quetiapine many years ago but only gave it about 3 days..I couldnt handle the grogginess the day after..I'm prepared for that this time and because i'm not working at present sleeping in is not a issue..My Diagnosis has waxed and waned slightly over the years..Various Diagnosis have Been OCPD/OCD...Mixed Anxiety/Depression ..I also tend to be on the paranoid side hence antipsychotics....Ok so just a few questions about quetiapine..I'm also on Mirtazapine so  hopefully if i get quetiapine perscribed it will be the combo of the two..I'm willing to lower my does of mirt if i get a good response to quetiapine..

1) Does the grogginess go over time? With Mirt i've been on it 7 years and depending on which brand i get it still has sedative qualitys..

2)How effective is Quetiapine for depression?? 

3) I've read it has a general calming effect..Does this effect run over into the next day or is it more calming because of its sedative effects?

4)Does it work well for ruminations/Obsessive thought loops etc

5) Does it blunt the emotions were basically u dont feel anything other than Numb??

I understand that untill a med is tried then its hard to say how a person responds and if they even get side effects..I'm just looking for a general over view...Also the Pdoc may not perscribe it thats a reality however i dont think he will have issue as the ECG has been done...

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1 hour ago, GrannyG81 said:

 

1) Does the grogginess go over time?  --for me, yes.  It took about a week for my body to get used to my starting dose of Quetiapine.  Even that starting dose of 12.5 mg really knocked me back to start out, and now that I've been regularly taking it for sleep for around 9 months I take 25-100mg at night and 25-50 mg daily as an add-on PRN for anxiety.  I don't have any trouble getting out of bed in the morning now.  I remember the first week taking it was really rough and I didn't think I could stay on it, I was so logey in the mornings.  That effect recurred a bit with dosage increases, too, but my body has now adjusted.

2)How effective is Quetiapine for depression??  -- for me, not very.  It maybe helps my depression feel somewhat less "immediate" or "critical", if that makes any sense?    

3) I've read it has a general calming effect..Does this effect run over into the next day or is it more calming because of its sedative effects? -- I experience a bit of a calmness "hangover" effect into the next day after taking it at night.  

4)Does it work well for ruminations/Obsessive thought loops etc  -- a little, for me.  Maybe 10% less than when I'm not taking it?

5) Does it blunt the emotions were basically u dont feel anything other than Numb??  --not once I got past the dosage adjustment stages.  

For me it's been a decent med to help me sleep and to take the "edge" off during daytime.   If you end up trying it, I hope it gives you some relief from symptoms.

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5 hours ago, GrannyG81 said:

 

1. Seroquel made mornings very hard for me. The day grogginess goes away after awhile though. Once I finally did wake up, I was awake and fine for the rest of the day. I was able to take it as a PRN during the day in low doses without grogginess as well. I was on the maximum dose of 800mg for many many years.

2. I took it for paranoia/psychosis.

3. I remember it quieting my thoughts. I’m sure that calmed me down as a result. I had to take some during the day and the rest during the night because I needed help during the day and just taking it at night didn’t quite tide me over during the day. 

4. I took it for psychosis but as far as thoughts go, I couldn’t function without it. 

5. I found it blunting but it was better than being overwhelmed by symptoms. I stopped taking it because it only worked enough to get me through a day, I was still very symptomatic.  

Edited by saintalto
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I take the IR for sleep, and it works in conjunction with my Ambien. At this point I’ve been taking both of them for so long that I couldn’t begin to tell you if it makes me groggy or not.

For several years I took 300 mgs XR as an antidepressant, in conjunction with lamictal and escitalopram. I think it worked reasonably well, at least at first. I may have stayed on it longer than I needed to. I stopped taking it because of weight gain.

I think it was good for my anxiety, generally speaking. 

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Appreciate the Feedback @fantod @saintalto and @Gearhead...I'm willing to give it a go and see..I just need something that helps to quiet my mind down and help with the anxiety/obsessive thoughts and i'm pretty sure the Pdoc will be ok ...He originally perscribed me abilify but i'm not taking it..I dont want anything that stimulates me..Those type of meds dont agree with me..I need more sedative type medication...I'll update when i've spoke to him on thursday..Cheers

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@GrannyG81

I took seroquel IR and then XR for over 10 years At 800 mg. It was really helpful for the time I was on it. I finally got off due to weight gain and the fact that zyprexa (olanzapine) works better for me with no weight gain.

1) Does the grogginess go over time? For me yes. I took the IR 4 times a day so it did get better and I needed all day coverage so I had to take it 4 times a day. When I switched to the XR (once a day dosing much easier for me) I was no longer groggy at all ever on that formula of seroquel. 
 

2)How effective is Quetiapine for depression?? I took it for mania and psychosis. So I can’t say.

 

3) I've read it has a general calming effect..Does this effect run over into the next day or is it more calming because of its sedative effects? Well, the IR version I had to take multiple times a day for the calming effect to last all day. The XR I just had to take once a day. It is overall a very calming med. And I am a person that needs calming meds for sure.

 

4)Does it work well for ruminations/Obsessive thought loops etc? I can’t speak to that as I don’t have OCD and I took seroquel for mania and psychosis. 
 

5) Does it blunt the emotions were basically u dont feel anything other than Numb?? Not in my experience. I didn’t feel numb or feel that my emotions were blocked and I was taking 800 mg a day. Like I said, it was an excellent calming med that prevented mania pretty much completely for me and worked so so for psychosis for me. But I have treatment resistant psychosis so it’s hard to treat. I took it for over 10 years and it was good to me. But olanzapine is my miracle med and I don’t gain weight on it so I finally switched back to that instead.

 

Good luck! Are you trying the IR or the XR seroquel version? I personally preferred the XR but the IR is more sedating but I had to take it more times a day too. Tough call.

 

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Thanks for the Reply @Wonderful.Cheese I'm gunna discuss it on thursday with the Pdoc and see what he says...I was originally perscribed Abilify..This Pdoc is New and have only had 2 appointments with him..He Did say to me that Quetiapine would be good for someone like me when we first met but because i'd not had a ECG he wouldnt perscribe it and instead opted for abilify as he was ok with abilfy without a ECG because of its side effect profile...I think the idea was to try abilify and by that time i would of had my ECG etc plus of given abilify a fair trial and if it didnt work look at quetiapine..I missed one of my ECG appointments by mistake so at my next pdoc appointment i'd still not had it..I've talked myself out of trying abilify because of what i've read..I dont like the idea of anything activating..Like you i need meds that calm my brain not excite it...My ECG has been done now so i dont think the Pdoc will have any issue with Quetiapine especially as he was the first to suggest it....I'll mention both versions to him and see what he thinks is best..i'd imagine i'll start off on a low dose and see from there..I will keep everyone on this post updated...I really do appreciate the feedback ..Thanks

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