clinic Posted April 19, 2020 Share Posted April 19, 2020 (edited) I takeclozapine 175mgparoxetine cr 37.5mgclobazam 10mgescitalopram 10mg 10mg lexapro(escitalopram) at 8am is working so damn well for ocd but I'm so tired/sleepy that i wake up at 3-4pm on it. I have tried all the different timings of taking the meds like divided dosing, all dose at bedtime etc - they don't work. I believe bedtime dosing doesnt work cuz clozapine decreases serotonin and lexapro increases it, so they prolly cancel each other out ? Only 10mg at 8am works perfectly. What should i do about tiredness and being sleepy ? Modafinil and coffee worsens my psychosis. My next option would be to stop lexapro and add prozac - but it inhibits 2d6 and 3A4 - which would further increase clozapine and paroxetine blood levels. Increasing clozapine is bad - cuz it worsens ocd and anxiety and makes me less likely to tolerate any SSRI. Edited April 19, 2020 by clinic Link to comment Share on other sites More sharing options...
notloki Posted April 19, 2020 Share Posted April 19, 2020 How long have you been taking Lexepro ? Link to comment Share on other sites More sharing options...
clinic Posted April 25, 2020 Author Share Posted April 25, 2020 (edited) On 4/20/2020 at 1:08 AM, notloki said: How long have you been taking Lexepro ? Its been a month, but i experimented different doses and timings of the med during this time. So i guess steady state of lexapro has not developed consistently. I'm not feeling tired right now. But since past couple of days ocd has been super bad. Im thinking if my meds are fake, cuz ocd was better few weeks ago. Edited April 25, 2020 by clinic Link to comment Share on other sites More sharing options...
clinic Posted April 27, 2020 Author Share Posted April 27, 2020 I got lexapro from another pharmacy, i feel like its working again. Plus tiredness is back. Link to comment Share on other sites More sharing options...
clinic Posted May 2, 2020 Author Share Posted May 2, 2020 Update: My meds were not fake. Lexapro 10mg is not working for OCD, and 15mg makes me cry. I will ask pdoc to reduce clozapine to 150 and add risperidone. After reducing clozapine to 150, i will try increasing lexapro again. If that fails, i will try prozac. Link to comment Share on other sites More sharing options...
Butterflykisses Posted May 2, 2020 Share Posted May 2, 2020 I empathize with you...I am on Clozapine and my OCD is through the roof. I am on the max dose of Paxil and its stopped working. Link to comment Share on other sites More sharing options...
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