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Escitalopram vs Sertraline  

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  1. 1. Which one did you like more?

    • Escitalopram
    • Sertraline
    • equally good
    • equally shitty

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Both are second-generation SSRIs, both exhibit minimal drug interactions via Cytochrome P450, both are the most prescribed SSRIs and are considered first line antidepressants. Who's been taking both and what were your experiences? (How did they compare to each other?). I am looking forward to read your experiences...

Which one did you like more?

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Everyone has a different reaction to different meds, but say whatever you want about all SSRIs being the same - I'll never agree with this claim.

Twice on Sertraline, all dose range (50mg-300mg) worked great for mood, has some kind of energizing/calming effect. Something like a weak Ritalin-ish feel.

Escitalopram, once, low dose. Did nothing for my depression, if not making it worse... and killed my sex drive.

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escitalopram and zoloft were the first and second meds i tried, respectively.

i forget my dose of escitalopram, but it wasn't very high. it put me in a total fog. i was sleepy and not very present.

sertraline i think went up to 200 mg. it was good for energy and mood, but exacerbated my obsessive racing thoughts and made my anxiety worse. even with .5 mg risperidone added, i was still anxious with fast thoughts (not mania -- just good old GAD with a splash of obsessiveness). my pdoc took me off of it in exchange for something more sedating.

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  • 1 month later...

Major differences, sertraline tends to be stimulating where escitalopram tends to be more calming. Sertraline is more likely comparatively in my experience to cause diarrhea. However it was less likely to cause anhedonia. I only ever took sertraline at 25mg and 50mg successfully, 75mg started to go in the wrong direction. Hard to explain but not the point of this post. Escitalopram ever only took 10mg but that was quite sufficient for my depression and it works quickly. Problem is it makes you feel like a complacent slug after long-term use and caused more anhedonia than sertraline as I said before.

Edited by browri
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